Sesamin (SSM) is a water-insoluble compound that is easily eliminated by liver metabolism.\nTo improve the solubility and bioavailability of SSM, this study developed and characterized a\nself-nanoemulsifying drug delivery system (SNEDDS) for the oral delivery of SSM and conducted\npharmacokinetic assessments. Oil and surfactant materials suitable for SNEDDS preparation were\nselected on the basis of their saturation solubility at 37 0.5C. The mixing ratios of excipients were\ndetermined on the basis of their dispersibility, transmittance (%), droplet sizes, and polydispersity\nindex. An SNEDDS (F10) formulation comprising glyceryl trioctanoate, polyoxyethylene castor oil,\nand Tween 20 at a ratio of 10:10:80 (w/w/w) was the optimal formulation. This formulation maintained\nover 90% of its contents in different storage environments for 12 weeks. After the self-emulsification\nof SNEDDS, the SSM dispersed droplet size was 66.4 31.4 nm, intestinal permeability increased\nby more than three-fold, relative bioavailability increased by approximately 12.9-fold, and absolute\nbioavailability increased from 0.3% to 4.4%. Accordingly, the developed SNEDDS formulation can\npreserve SSMâ??s solubility, permeability, and bioavailability. Therefore, this SNEDDS formulation\nhas great potential for the oral administration of SSM, which can enhance its pharmacological\napplication value.
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